Glycerophosphodiester phosphodiesterase

In enzymology, a glycerophosphodiester phosphodiesterase (EC 3.1.4.46) is an enzyme that catalyzes the chemical reaction

a glycerophosphodiester + H2O an alcohol + sn-glycerol 3-phosphate
glycerophosphodiester phosphodiesterase
Identifiers
EC number3.1.4.46
CAS number86280-59-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Glycerophosphodiester phosphodiesterase
Identifiers
SymbolGDP
PfamPF03009
Membranome584

Thus, the two substrates of this enzyme are glycerophosphodiester and H2O, whereas its two products are alcohol and sn-glycerol 3-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is glycerophosphodiester glycerophosphohydrolase. Other names in common use include gene hpd protein, glycerophosphoryl diester phosphodiesterase, and IgD-binding protein D. This enzyme participates in glycerophospholipid metabolism.

References

    • Larson TJ, Ehrmann M, Boos W (1983). "Periplasmic glycerophosphodiester phosphodiesterase of Escherichia coli, a new enzyme of the glp regulon". J. Biol. Chem. 258 (9): 5428–32. PMID 6304089.


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