Glycerophosphocholine phosphodiesterase
In enzymology, a glycerophosphocholine phosphodiesterase (EC 3.1.4.2) is an enzyme that catalyzes the chemical reaction
- sn-glycero-3-phosphocholine + H2O choline + sn-glycerol 3-phosphate
| glycerophosphocholine phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.2 | ||||||||
| CAS number | 9025-85-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are sn-glycero-3-phosphocholine and H2O, whereas its two products are choline and sn-glycerol 3-phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is sn-glycero-3-phosphocholine glycerophosphohydrolase. Other names in common use include glycerophosphinicocholine diesterase, glycerylphosphorylcholinediesterase, sn-glycero-3-phosphorylcholine diesterase, glycerolphosphorylcholine phosphodiesterase, and glycerophosphohydrolase. This enzyme participates in glycerophospholipid metabolism.
References
- Dawson RMC (1956). "Liver glycerylphosphorylcholine diesterase". Biochem. J. 62: 689–693.
- Hayaishi O, Kornberg A (1954). "Metabolism of phospholipides by bacterial enzymes". J. Biol. Chem. 206 (2): 647–63. PMID 13143024.
- Webster GR, Marples EA, Thompson RH (1957). "Glycerylphosphorylcholine diesterase activity in nervous tissue". Biochem. J. 65 (2): 374–377. PMC 1199879. PMID 13403918.