Glucuronate-2-sulfatase

In enzymology, a glucuronate-2-sulfatase (EC 3.1.6.18) is an enzyme that catalyzes the chemical reaction of cleaving off the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.

glucuronate-2-sulfatase
Identifiers
EC number3.1.6.18
CAS number98597-45-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase. This enzyme is also called glucurono-2-sulfatase. This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.

References

    • Shaklee PN, Glaser JH, Conrad HE (1985). "A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans". J. Biol. Chem. 260 (16): 9146–9. PMID 4019466.


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