Gamma-D-Glutamyl-meso-diaminopimelate peptidase

Gamma-D-glutamyl-meso-diaminopimelate peptidase (EC 3.4.19.11, endopeptidase I, gamma-D-glutamyldiaminopimelate endopeptidase, gamma-D-glutamyl-L-meso-diaminopimelate peptidoglycan hydrolase, gamma-glutamyl-L-meso-diaminopimelyl endopeptidase, gamma-D-glutamyl-meso-diaminopimelate endopeptidase, gamma-D-glutamyl-meso-diaminopimelic peptidoglycan hydrolase, gamma-D-glutamyl-meso-diaminopimelic endopeptidase, gamma-D-glutamyl-meso-D-aminopimelic endopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of gamma-D-glutamyl bonds to the L-terminus (position 7) of meso-diaminopimelic acid (meso-A2pm) in 7-(L-Ala-gamma-D-Glu)-meso-A2pm and 7-(L-Ala-gamma-D-Glu)-7-(D-Ala)-meso-A2pm. It is required that the D-terminal amino and carboxy groups of meso-A2pm are unsubstituted
Gamma-D-glutamyl-meso-diaminopimelate peptidase
Identifiers
EC number3.4.19.11
CAS number62572-28-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This metallopeptidase is isolate from Bacillus sphaericus.

References

  1. Arminjon F, Guinand M, Vacheron MJ, Michel G (March 1977). "Specificity profiles of the membrane-bound gamma-D-glutamyl-(L)meso-diaminopimelateendopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602". European Journal of Biochemistry. 73 (2): 557–65. doi:10.1111/j.1432-1033.1977.tb11351.x. PMID 849747.
  2. Garnier M, Vacheron MJ, Guinand M, Michel G (May 1985). "Purification and partial characterization of the extracellular gamma-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602". European Journal of Biochemistry. 148 (3): 539–43. doi:10.1111/j.1432-1033.1985.tb08873.x. PMID 3922755.
  3. Hourdou ML, Guinand M, Vacheron MJ, Michel G, Denoroy L, Duez C, Englebert S, Joris B, Weber G, Ghuysen JM (June 1993). "Characterization of the sporulation-related gamma-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein". The Biochemical Journal. 292 (2): 563–70. doi:10.1042/bj2920563. PMC 1134247. PMID 8503890.
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