Flavone 7-O-beta-glucosyltransferase
In enzymology, a flavone 7-O-beta-glucosyltransferase (EC 2.4.1.81) is an enzyme that catalyzes the chemical reaction
- UDP-glucose + 5,7,3',4'-tetrahydroxyflavone UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone
| flavone 7-O-beta-glucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.81 | ||||||||
| CAS number | 37332-50-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are UDP-glucose and 5,7,3',4'-tetrahydroxyflavone (luteolin), whereas its two products are UDP and 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone (cynaroside).
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase. Other names in common use include UDP-glucose-apigenin beta-glucosyltransferase, UDP-glucose-luteolin beta-D-glucosyltransferase, uridine diphosphoglucose-luteolin glucosyltransferase, uridine diphosphoglucose-apigenin 7-O-glucosyltransferase, and UDP-glucosyltransferase. This enzyme participates in flavonoid biosynthesis.
References
- Sutter A, Ortmann R, Grisebach H (1972). "Purification and properties of an enzyme from cell suspension cultures of parsley catalyzing the transfer of D-glucose from UDP-D-glucose to flavonoids". Biochim. Biophys. Acta. 258 (1): 71–87. doi:10.1016/0005-2744(72)90967-9. PMID 5058406.