UGT2B10

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.[4][5]

UGT2B10
Identifiers
Aliases	UGT2B10, UDPGT2B10, UDP glucuronosyltransferase family 2 member B10
External IDs	OMIM: 600070 MGI: 2140962 HomoloGene: 117389 GeneCards: UGT2B10
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 68,815,994 bp[1] End 68,832,023 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity, transferring glycosyl groups • transferase activity • transferase activity, transferring hexosyl groups • glucuronosyltransferase activity • UDP-glycosyltransferase activity Cellular component • integral component of membrane • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • endoplasmic reticulum • membrane Biological process • metabolism • lipid metabolism Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7365	100727
Ensembl	ENSG00000275190 ENSG00000109181	n/a
UniProt	P36537	n/a
RefSeq (mRNA)	NM_001290091 NM_001075 NM_001144767	NM_153598
RefSeq (protein)	NP_001066 NP_001138239 NP_001277020	n/a
Location (UCSC)	Chr 4: 68.82 – 68.83 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (Aug 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochem Biophys Res Commun. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.
5. "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".

Further reading

• Chen G, Dellinger RW, Gallagher CJ, et al. (2008). "Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines". Pharmacogenet. Genomics. 18 (3): 181–91. doi:10.1097/FPC.0b013e3282f4dbdd. PMID 18300939.
• Chen G, Blevins-Primeau AS, Dellinger RW, et al. (2007). "Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism". Cancer Res. 67 (19): 9024–9. doi:10.1158/0008-5472.CAN-07-2245. PMID 17909004.
• Kaivosaari S, Toivonen P, Hesse LM, et al. (2007). "Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10". Mol. Pharmacol. 72 (3): 761–8. doi:10.1124/mol.107.037093. PMID 17576790.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.
• Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.