UGT1A8

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.[4][5][6]

UGT1A8
Identifiers
Aliases	UGT1A8, UDPGT, UDPGT 1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H, UDP glucuronosyltransferase family 1 member A8, UGT1-01, UGT-1A, UGT1.1, UGT1A, hUG-BR1, UGT1, GNT1, UGT1A1
External IDs	OMIM: 606433 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A8
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,617,645 bp[1] End 233,773,310 bp[1]
Gene ontology Molecular function • transferase activity • GO:0048551 enzyme inhibitor activity • retinoic acid binding • transferase activity, transferring hexosyl groups • protein homodimerization activity • transferase activity, transferring glycosyl groups • glucuronosyltransferase activity • fatty acid binding • steroid binding • drug binding • protein heterodimerization activity • enzyme binding • UDP-glycosyltransferase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • steroid metabolic process • coumarin metabolic process • negative regulation of steroid metabolic process • retinoic acid metabolic process • negative regulation of cellular glucuronidation • fatty acid metabolic process • cellular glucuronidation • flavonoid glucuronidation • xenobiotic glucuronidation • drug metabolic process • flavone metabolic process • metabolism • negative regulation of glucuronosyltransferase activity • negative regulation of fatty acid metabolic process • GO:0048553 negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54576	394434
Ensembl	ENSG00000242366	n/a
UniProt	Q9HAW9	Q62452
RefSeq (mRNA)	NM_019076	NM_201644
RefSeq (protein)	NP_061949	NP_964006
Location (UCSC)	Chr 2: 233.62 – 233.77 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000242366 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. PMID 1339448.
5. Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics. 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID 12042666.
6. "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.