FGD2

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.[5]

FGD2
Identifiers
Aliases	FGD2, ZFYVE4, FYVE, RhoGEF and PH domain containing 2
External IDs	OMIM: 605091 MGI: 1347084 HomoloGene: 8438 GeneCards: FGD2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 37,005,646 bp[1] End 37,029,069 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 15.26 cM|17 A3.3 Start 29,360,914 bp[2] End 29,379,661 bp[2]
Gene ontology Molecular function • phosphatidylinositol phosphate binding • metal ion binding • small GTPase binding • GO:0001948 protein binding • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • endosome • Golgi apparatus • cell projection • early endosome membrane • membrane • ruffle • cell membrane • ruffle membrane • early endosome • cytoskeleton • cell nucleus • lamellipodium Biological process • positive regulation of JUN kinase activity • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • filopodium assembly • cytoskeleton organization • regulation of cell shape • positive regulation of apoptotic process • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • actin cytoskeleton organization • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221472	26382
Ensembl	ENSG00000146192	ENSMUSG00000024013
UniProt	Q7Z6J4	Q8BY35
RefSeq (mRNA)	NM_173558	NM_001159538 NM_013710
RefSeq (protein)	NP_775829	NP_001153010 NP_038738
Location (UCSC)	Chr 6: 37.01 – 37.03 Mb	Chr 17: 29.36 – 29.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

It is a member of the FYVE, RhoGEF and PH domain containing family.

References

1. GRCh38: Ensembl release 89: ENSG00000146192 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024013 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FYVE".

Further reading

• Salehi AH, Xanthoudakis S, Barker PA (2002). "NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway". J. Biol. Chem. 277 (50): 48043–50. doi:10.1074/jbc.M205324200. PMID 12376548.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Hattori A, Okumura K, Nagase T, et al. (2000). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Pasteris NG, Gorski JL (1999). "Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues". Genomics. 60 (1): 57–66. doi:10.1006/geno.1999.5903. PMID 10458911.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Harrington AW, Kim JY, Yoon SO (2002). "Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis". J. Neurosci. 22 (1): 156–66. doi:10.1523/JNEUROSCI.22-01-00156.2002. PMC 6757583. PMID 11756498.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rabizadeh S, Bredesen DE (2003). "Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR)". Cytokine Growth Factor Rev. 14 (3–4): 225–39. doi:10.1016/S1359-6101(03)00018-2. PMID 12787561.
• Huber C, Mårtensson A, Bokoch GM, et al. (2008). "FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles". J. Biol. Chem. 283 (49): 34002–12. doi:10.1074/jbc.M803957200. PMC 2590680. PMID 18838382.
• Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC 1950914. PMID 17564959.