DOCK (protein)

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1wg7

Dedicator of cytokinesis
Identifiers
Symbol	Ded_cyto
Pfam	PF06920
InterPro	IPR026791
SCOPe	1wg7 / SUPFAM
CDD	cd11684
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1wg7

DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.[1] DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP.

DOCK family proteins are categorised into four subfamilies based on their sequence homology:

DOCK-A subfamily
- Dock180 (also known as Dock1)
- Dock2
- Dock5
DOCK-B subfamily
- Dock3 (also known as MOCA and PBP)
- Dock4
DOCK-C subfamily (also known as Zir subfamily)
- Dock6 (also known as Zir1)
- Dock7 (also known as Zir2)
- Dock8 (also known as Zir3)
DOCK-D subfamily (also known as Zizimin subfamily)
- Dock9 (also known as Zizimin1)
- Dock10 (also known as Zizimin3)
- Dock11 (also known as Zizimin2)

References

Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". Journal of Cell Science. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.

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[pmid12432077-1] Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". Journal of Cell Science. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.