RGS5

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.[5][6]

RGS5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5, regulator of G protein signaling 5
External IDsOMIM: 603276 MGI: 1098434 HomoloGene: 2682 GeneCards: RGS5
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start163,111,121 bp[1]
End163,321,791 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8490

19737

Ensembl

ENSG00000143248

ENSMUSG00000026678

UniProt

O15539

O08850

RefSeq (mRNA)

NM_001195303
NM_001254748
NM_001254749
NM_003617
NM_025226

NM_009063
NM_001313705

RefSeq (protein)

NP_001182232
NP_001241677
NP_001241678
NP_003608
NP_003608.1

NP_001300634
NP_033089

Location (UCSC)Chr 1: 163.11 – 163.32 MbChr 1: 169.66 – 169.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM][6]

Interactions

RGS5 has been shown to interact with GNAO1,[7][8] GNAI2[7][8] and GNAI3.[7][8]

gollark: Yes, you are.
gollark: *Are* you in heavserver yet?
gollark: [REDACTED]
gollark: Why not?
gollark: Even if you die, we'll reverse-engineer a good approximation of your mindstate from all available data and add it to heavserver.

References

  1. GRCh38: Ensembl release 89: ENSG00000143248 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026678 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet. 43 (3): 202–5. doi:10.1007/s100380050071. PMID 9747037.
  6. "Entrez Gene: RGS5 regulator of G-protein signalling 5".
  7. Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. UNITED STATES. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.
  8. Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. England. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.

Further reading

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