RGS12

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.[5][6]

RGS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBZ, 2KV8
Identifiers
Aliases	RGS12, regulator of G protein signaling 12
External IDs	OMIM: 602512 MGI: 1918979 HomoloGene: 2195 GeneCards: RGS12
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 3,293,028 bp[1] End 3,439,913 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B2|5 17.96 cM Start 34,949,445 bp[2] End 35,039,644 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0005083 GTPase regulator activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GTPase activity Cellular component • cytoplasm • cell projection • nuclear matrix • synapse • condensed nuclear chromosome • cell junction • dendrite • cell membrane • cell nucleus • nucleolus • cytosol Biological process • regulation of G-protein coupled receptor protein signaling pathway • transcription, DNA-templated • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of signal transduction • signal transduction • GO:0048552 regulation of catalytic activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6002	71729
Ensembl	ENSG00000159788	ENSMUSG00000029101
UniProt	O14924	Q8CGE9
RefSeq (mRNA)	NM_002926 NM_198227 NM_198229 NM_198230 NM_198430 NM_198432 NM_198587	NM_001163512 NM_173402
RefSeq (protein)	NP_002917 NP_937870 NP_937872	NP_001156984 NP_775578
Location (UCSC)	Chr 4: 3.29 – 3.44 Mb	Chr 5: 34.95 – 35.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.[6]

Interactions

RGS12 has been shown to interact with GNAI1,[7] GNAI3,[7] and the kappa opioid receptor.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000159788 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029101 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
6. "Entrez Gene: RGS12 regulator of G-protein signalling 12".
7. Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.
8. Gross, JD; Kaski, SW; Schmidt, KT; Cogan, ES; Boyt, KM; Wix, K; Schroer, AB; McElligott, ZA; Siderovski, DP; Setola, V (September 2019). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. PMC 6785087. PMID 31141817.

Further reading

• Frohme M, Scharm B, Delius H, et al. (2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue". Ann. N. Y. Acad. Sci. 910 (1): 85–104, discussion 104–5. Bibcode:2000NYASA.910...85F. doi:10.1111/j.1749-6632.2000.tb06703.x. PMID 10911908.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Snow BE, Antonio L, Suggs S, et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
• Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products". J. Biol. Chem. 275 (38): 29660–71. doi:10.1074/jbc.M000330200. PMID 10869340.
• Schiff ML, Siderovski DP, Jordan JD, et al. (2001). "Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel". Nature. 408 (6813): 723–7. doi:10.1038/35047093. PMID 11130074.
• Kimple RJ, De Vries L, Tronchère H, et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
• Snow BE, Brothers GM, Siderovski DP (2002). Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain. Meth. Enzymol. Methods in Enzymology. 344. pp. 740–61. doi:10.1016/S0076-6879(02)44752-0. ISBN 9780121822453. PMID 11771424.
• Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
• Chatterjee TK, Fisher RA (2002). "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression". Mol. Cell. Biol. 22 (12): 4334–45. doi:10.1128/MCB.22.12.4334-4345.2002. PMC 133853. PMID 12024043.
• Potocnik U, Glavac D, Ravnik-Glavac M (2003). "Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability". Genes Chromosomes Cancer. 36 (1): 48–56. doi:10.1002/gcc.10141. PMID 12461749.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Yang S, Li YP (2007). "RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro". J. Bone Miner. Res. 22 (1): 45–54. doi:10.1359/jbmr.061007. PMC 3559086. PMID 17042716.
• Gross, J. D.; Kaski, S. W.; Schroer, A. B.; Wix, K. A.; Siderovski, D. P.; Setola, V. (2018). "Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants". J. Psychopharmacol. 32 (2): 191–203. doi:10.1177/0269881117742100. PMC 5942192. PMID 29364035.
• Gross, Joshua D.; Kaski, Shane W.; Schmidt, Karl T.; Cogan, Elizabeth S.; Boyt, Kristen M.; Wix, Kim; Schroer, Adam B.; McElligott, Zoe A.; Siderovski, David P. (2019-05-29). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. ISSN 1740-634X. PMID 31141817.
• Schroer, AB; Mohamed, JS; Willard, MD; Setola, V; Oestreich, E; Siderovski, DP (2019). "A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation". PLOS ONE. 14 (8): e0216167. doi:10.1371/journal.pone.0216167. PMC 6691989. PMID 31408461.