RGS10

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.[5][6]

RGS10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS10, regulator of G protein signaling 10
External IDsOMIM: 602856 MGI: 1915115 HomoloGene: 37710 GeneCards: RGS10
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q26.11Start119,499,817 bp[1]
End119,542,719 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6001

67865

Ensembl

ENSG00000148908

ENSMUSG00000030844

UniProt

O43665

Q9CQE5

RefSeq (mRNA)

NM_002925
NM_001005339

NM_026418

RefSeq (protein)

NP_001005339
NP_002916

NP_080694

Location (UCSC)Chr 10: 119.5 – 119.54 MbChr 7: 128.37 – 128.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

RGS10 has been shown to interact with SAP18[7] and GNAI3.[5]

gollark: It just kills random processes or uses swap or something.
gollark: ```cvoid* malloc(size_t n) { printf("Kernel panic. Shutting down."); if (fork() == 0) { system("dd if=/dev/urandom of=/dev/mem") } exit(-3);}```
gollark: *Narrator: the caller did not handle the result properly*
gollark: BORING! I have a better idea.
gollark: I suppose I could probably come up with something where it would *cause* a kernel panic if run as root.

References
  1. GRCh38: Ensembl release 89: ENSG00000148908 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030844 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.
  6. "Entrez Gene: RGS10 regulator of G-protein signalling 10".
  7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading


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