Dolichylphosphate-glucose phosphodiesterase

In enzymology, a dolichylphosphate-glucose phosphodiesterase (EC 3.1.4.48) is an enzyme that catalyzes the chemical reaction

dolichyl beta-D-glucosyl phosphate + H2O dolichyl phosphate + D-glucose
dolichylphosphate-glucose phosphodiesterase
Identifiers
EC number3.1.4.48
CAS number89287-42-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are dolichyl beta-D-glucosyl phosphate and H2O, whereas its two products are dolichyl phosphate and D-glucose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase. Other names in common use include dolichol phosphoglucose phosphodiesterase, and Dol-P-Glc phosphodiesterase. This enzyme participates in n-glycan biosynthesis.

References

    • Crean EV (1984). "Synthesis and degradation of dolichyl phosphoryl glucose by the cellular slime mold, Dictyostelium discoideum". Biochim. Biophys. Acta. 792: 149–157. doi:10.1016/0005-2760(84)90216-9.


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