Disulfoglucosamine-6-sulfatase
In enzymology, a disulfoglucosamine-6-sulfatase (EC 3.1.6.11) is an enzyme that catalyzes the chemical reaction
- N,6-O-disulfo-D-glucosamine + H2O N-sulfo-D-glucosamine + sulfate
| disulfoglucosamine-6-sulfatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.6.11 | ||||||||
| CAS number | 37288-32-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are N,6-O-disulfo-D-glucosamine and H2O, whereas its two products are N-sulfo-D-glucosamine and sulfate.
This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is N,6-O-disulfo-D-glucosamine 6-sulfohydrolase. Other names in common use include N-sulfoglucosamine-6-sulfatase, and 6,N-disulfoglucosamine 6-O-sulfohydrolase.
References
- Dietrich CP (January 1969). "Enzymic degradation of heparin. A sulphamidase and a sulphoesterase from Flavobacterium heparinum". The Biochemical Journal. 111 (1): 91–5. PMC 1187498. PMID 5775690.
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