Dipeptidyl-peptidase III

Dipeptidyl-peptidase III (EC 3.4.14.4, dipeptidyl aminopeptidase III, dipeptidyl arylamidase III, enkephalinase B, red cell angiotensinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
Dipeptidyl-peptidase III
Identifiers
EC number3.4.14.4
CAS number77464-87-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This cytosolic peptidase that is active at neutral pH.

References

  1. McDonald JK (1998). "Dipeptidyl-peptidase III". In Barrett AJ, Rawlings NA, Woessner JG (eds.). Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 536–538.
  2. Fukasawa K, Fukasawa KM, Iwamoto H, Hirose J, Harada M (June 1999). "The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme". Biochemistry. 38 (26): 8299–303. doi:10.1021/bi9904959. PMID 10387075.


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