Dihydrofolic acid
Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase.[1] Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.
![](../I/m/page1-220px-Pathway_of_tetrahydrofolate_and_antimetabolites.pdf.jpg)
Pathway of tetrahydrofolate and antimetabolites
![]() | |
![]() | |
Names | |
---|---|
IUPAC name
N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid | |
Other names
H2folate, DH | |
Identifiers | |
3D model (JSmol) |
|
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.116.435 |
MeSH | dihydrofolate |
PubChem CID |
|
UNII | |
| |
| |
Properties | |
C19H21N7O6 | |
Molar mass | 443.414 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
![]() ![]() ![]() | |
Infobox references | |
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Fluorouracil (5-FU) Activity edit
- The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
gollark: GNOME < LXDE
gollark: Unfortunately, 24% still get through.
gollark: I spread a [REDACTED] metaapioformic agent into the server to make 76% of gnobody messages appear to be merely extra space in the message view.
gollark: Only memetically.
gollark: National security reasons and [REDACTED] compliance protocols.
References
- Maharaj G, Selinsky BS, Appleman JR, Perlman M, London RE, Blakley RL (May 1990). "Dissociation constants for dihydrofolic acid and dihydrobiopterin and implications for mechanistic models for dihydrofolate reductase". Biochemistry. 29 (19): 4554–60. doi:10.1021/bi00471a008. PMID 2372539.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.