CMP-N-acylneuraminate phosphodiesterase

In enzymology, a CMP-N-acylneuraminate phosphodiesterase (EC 3.1.4.40) is an enzyme that catalyzes the chemical reaction

CMP-N-acylneuraminate + H2O CMP + N-acylneuraminate
CMP-N-acylneuraminate phosphodiesterase
Identifiers
EC number3.1.4.40
CAS number55326-41-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are CMP-N-acylneuraminate and H2O, whereas its two products are CMP and N-acylneuraminate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is CMP-N-acylneuraminate N-acylneuraminohydrolase. Other names in common use include CMP-sialate hydrolase, CMP-sialic acid hydrolase, CMP-N-acylneuraminic acid hydrolase, cytidine monophosphosialic hydrolase, cytidine monophosphosialate hydrolase, cytidine monophosphate-N-acetylneuraminic acid hydrolase, and CMP-N-acetylneuraminate hydrolase.

References

    • Kean EL, Bighouse KJ (1974). "Cytidine 5'-monophosphosialic acid hydrolase. Subcellular location and properties". J. Biol. Chem. 249 (24): 7813–23. PMID 4372219.


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