Aminopeptidase S

Aminopeptidase S (EC 3.4.11.24, Mername-AA022 peptidase, SGAP, aminopeptidase (Streptomyces griseus), Streptomyces griseus aminopeptidase, S. griseus AP, double-zinc aminopeptidase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues
Aminopeptidase S
Identifiers
EC number3.4.11.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme contains two zinc molecules in its active site and is activated by Ca2+.

References

  1. Spungin A, Blumberg S (August 1989). "Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme". European Journal of Biochemistry. 183 (2): 471–7. doi:10.1111/j.1432-1033.1989.tb14952.x. PMID 2503378.
  2. Ben-Meir D, Spungin A, Ashkenazi R, Blumberg S (February 1993). "Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution". European Journal of Biochemistry. 212 (1): 107–12. doi:10.1111/j.1432-1033.1993.tb17639.x. PMID 8444149.
  3. Arima J, Uesugi Y, Iwabuchi M, Hatanaka T (May 2006). "Study on peptide hydrolysis by aminopeptidases from Streptomyces griseus, Streptomyces septatus and Aeromonas proteolytica". Applied Microbiology and Biotechnology. 70 (5): 541–7. doi:10.1007/s00253-005-0105-8. PMID 16080009.
  4. Fundoiano-Hershcovitz Y, Rabinovitch L, Langut Y, Reiland V, Shoham G, Shoham Y (July 2004). "Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus". FEBS Letters. 571 (1–3): 192–6. doi:10.1016/j.febslet.2004.07.001. PMID 15280041.
  5. Gilboa R, Greenblatt HM, Perach M, Spungin-Bialik A, Lessel U, Wohlfahrt G, Schomburg D, Blumberg S, Shoham G (May 2000). "Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution". Acta Crystallographica Section D. 56 (Pt 5): 551–8. doi:10.1107/s0907444900002420. PMID 10771423.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.