Alpha-amino-acid esterase
In enzymology, an alpha-amino-acid esterase (EC 3.1.1.43) is an enzyme that catalyzes the chemical reaction
- an alpha-amino acid ester + H2O an alpha-amino acid + an alcohol
| alpha-amino-acid esterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.43 | ||||||||
| CAS number | 74506-40-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are alpha-amino acid ester and H2O, whereas its two products are alpha-amino acid and alcohol.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is alpha-amino-acid-ester aminoacylhydrolase. This enzyme is also called alpha-amino acid ester hydrolase.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1MPX, 1NX9, 1RYY, 2B4K, and 2B9V.
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References
- Kato K, Kawahara K, Takahashi T, Kakinuma A (1980). "Purification of an alpha-amino acid ester hydrolase from Xanthomonas citri". Agric. Biol. Chem. 44: 1069–1074. doi:10.1271/bbb1961.44.1069.
- Kato K, Kawahara K, Takahashi T, Kakinuma A (1980). "Substrate specificity of an alpha-amino acid ester hydrolase from Xanthomonas citri". Agric. Biol. Chem. 44: 1075–1081. doi:10.1271/bbb1961.44.1075.
- Takahashi T, Yamazaki Y, Kato K (1974). "Substrate specificity of an alpha-amino acid ester hydrolase produced by Acetobacter turbidans A.T.C.C. 9325". Biochem. J. 137 (3): 497–503. doi:10.1042/bj1370497. PMC 1166149. PMID 4424889.
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