Alkylacetylglycerophosphatase
In enzymology, an alkylacetylglycerophosphatase (EC 3.1.3.59) is an enzyme that catalyzes the chemical reaction
- 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O 1-alkyl-2-acetyl-sn-glycerol + phosphate
| alkylacetylglycerophosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.59 | ||||||||
| CAS number | 102925-45-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphate and H2O, whereas its two products are 1-alkyl-2-acetyl-sn-glycerol and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase. Other names in common use include 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase, and alkylacetylglycerophosphate phosphatase. This enzyme participates in ether lipid metabolism.
References
- Lee TC, Malone B, Snyder F (1986). "A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen". J. Biol. Chem. 261 (12): 5373–7. PMID 3007498.
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