Acylaminoacyl-peptidase

Acylaminoacyl-peptidase (EC 3.4.19.1, acylamino-acid-releasing enzyme, N-acylpeptide hydrolase, N-formylmethionine (fMet) aminopeptidase, alpha-N-acylpeptide hydrolase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide
Acylaminoacyl-peptidase
Identifiers
EC number3.4.19.1
CAS number73562-30-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is active at neutral pH.

References

  1. Tsunasawa S, Narita K, Ogata K (January 1975). "Purification and properties of acylamino acid-releasing enzyme from rat liver". Journal of Biochemistry. 77 (1?): 89–102. PMID 1137989.
  2. Unger T, Nagelschmidt M, Struck H (June 1979). "N-Acetylaminoacyl-p-nitranilidase from human placenta. Purification and some properties". European Journal of Biochemistry. 97 (1): 205–11. doi:10.1111/j.1432-1033.1979.tb13104.x. PMID 477668.
  3. Kobayashi K, Smith JA (August 1987). "Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction". The Journal of Biological Chemistry. 262 (24): 11435–45. PMID 3305492.
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