Acetylajmaline esterase

Acetylajmaline esterase (EC 3.1.1.80, AAE, 2beta(R)-17-O-acetylajmalan:acetylesterase, acetylajmalan esterase) is an enzyme with systematic name 17-O-acetylajmaline O-acetylhydrolase.[1][2] This enzyme catalyses the following chemical reaction

(1) 17-O-acetylajmaline + H2O ajmaline + acetate
(2) 17-O-acetylnorajmaline + H2O norajmaline + acetate
Acetylajmaline esterase
Identifiers
EC number3.1.1.80
CAS number110183-46-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This plant enzyme mediates the last stages in the biosynthesis of the indole alkaloid ajmaline.

References

  1. Polz L, Schübel H, Stöckigt J (April 1987). "Characterization of 2 beta (R)-17-O-acetylajmalan: acetylesterase--a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid ajmaline". Zeitschrift für Naturforschung C. 42 (4): 333–42. PMID 2955586.
  2. Ruppert M, Woll J, Giritch A, Genady E, Ma X, Stöckigt J (November 2005). "Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system". Planta. 222 (5): 888–98. doi:10.1007/s00425-005-0031-0. PMID 16133216.
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