ADAM23

Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene.[5][6] It is a member of the ADAM family of extracellular matrix metalloproteinases.

ADAM23
Identifiers
AliasesADAM23, MDC-3, MDC3, ADAM metallopeptidase domain 23
External IDsOMIM: 603710 MGI: 1345162 HomoloGene: 2826 GeneCards: ADAM23
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.3Start206,443,532 bp[1]
End206,621,127 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8745

23792

Ensembl

ENSG00000114948

ENSMUSG00000025964

UniProt

O75077

Q9R1V7

RefSeq (mRNA)

NM_003812

NM_001177600
NM_011780

RefSeq (protein)

NP_003803

NP_035910

Location (UCSC)Chr 2: 206.44 – 206.62 MbChr 1: 63.45 – 63.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000114948 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025964 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sagane K, Ohya Y, Hasegawa Y, Tanaka I (Aug 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
  6. "Entrez Gene: ADAM23 ADAM metallopeptidase domain 23".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.