MMP24

Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene.[5][6]

MMP24
Identifiers
AliasesMMP24, MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5, matrix metallopeptidase 24
External IDsOMIM: 604871 MGI: 1341867 HomoloGene: 21331 GeneCards: MMP24
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.22Start35,226,690 bp[1]
End35,276,998 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10893

17391

Ensembl

ENSG00000125966

ENSMUSG00000027612

UniProt

Q9Y5R2

Q9R0S2

RefSeq (mRNA)

NM_006690

NM_010808

RefSeq (protein)

NP_006681

NP_034938

Location (UCSC)Chr 20: 35.23 – 35.28 MbChr 2: 155.78 – 155.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000125966 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027612 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, Lopez-Otin C (Jun 1999). "Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors". Cancer Res. 59 (11): 2570–6. PMID 10363975.
  6. "Entrez Gene: MMP24 matrix metallopeptidase 24 (membrane-inserted)".

Further reading



This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.