MMP21

Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.[5][6]

MMP21
Identifiers
Aliases	MMP21, MMP-21, HTX7, matrix metallopeptidase 21
External IDs	OMIM: 608416 MGI: 2664387 HomoloGene: 17519 GeneCards: MMP21
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.2 Start 125,753,580 bp[1] End 125,775,821 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 133,674,270 bp[2] End 133,680,061 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metallopeptidase activity • metal ion binding • zinc ion binding • metalloendopeptidase activity • peptidase activity • hydrolase activity Cellular component • extracellular region • extracellular matrix Biological process • hematopoietic progenitor cell differentiation • proteolysis • coronary vasculature development • determination of left/right symmetry • determination of heart left/right asymmetry • extracellular matrix organization • collagen catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	118856	214766
Ensembl	ENSG00000154485	ENSMUSG00000030981
UniProt	Q8N119	Q8K3F2
RefSeq (mRNA)	NM_147191	NM_152944 NM_001320216
RefSeq (protein)	NP_671724	NP_001307145 NP_694423
Location (UCSC)	Chr 10: 125.75 – 125.78 Mb	Chr 7: 133.67 – 133.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000154485 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030981 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.
6. "Entrez Gene: MMP21 matrix metallopeptidase 21".

Further reading

• Brinckerhoff CE, Matrisian LM (2002). "Matrix metalloproteinases: a tail of a frog that became a prince". Nat. Rev. Mol. Cell Biol. 3 (3): 207–14. doi:10.1038/nrm763. PMID 11994741.
• Bister V, Skoog T, Virolainen S, et al. (2008). "Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma". Mod. Pathol. 20 (11): 1128–40. doi:10.1038/modpathol.3800956. PMID 17873896.
• Skoog T, Ahokas K, Orsmark C, et al. (2006). "MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture". Exp. Dermatol. 15 (10): 775–83. doi:10.1111/j.1600-0625.2006.00460.x. PMID 16984259.
• Ahokas K, Karjalainen-Lindsberg ML, Sihvo E, et al. (2006). "Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer". Tumour Biol. 27 (3): 133–41. doi:10.1159/000092774. PMID 16641547.
• Shagisultanova EI, Novikova IA, Sidorenko YS, et al. (2004). "The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer". Anticancer Res. 24 (1): 199–201. PMID 15015597.
• Ahokas K, Lohi J, Illman SA, et al. (2004). "Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes". Lab. Invest. 83 (12): 1887–99. doi:10.1097/01.LAB.0000106721.86126.39. PMID 14691307.
• Marchenko GN, Marchenko ND, Strongin AY (2003). "The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein". Biochem. J. 372 (Pt 2): 503–15. doi:10.1042/BJ20030174. PMC 1223413. PMID 12617721.
• Ahokas K, Lohi J, Lohi H, et al. (2003). "Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer". Gene. 301 (1–2): 31–41. doi:10.1016/S0378-1119(02)01088-0. PMID 12490321.

External links

• The MEROPS online database for peptidases and their inhibitors: M10.026