Trimerelysin II

Trimerelysin II (EC 3.4.24.53, Trimeresurus metalloendopeptidase II, proteinase H2, H2-proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of Asn3-Gln, His10-Leu and Ala14-Leu in the insulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate of microbial collagenase
Trimerelysin II
Identifiers
EC number3.4.24.53
CAS number151125-15-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).

References

  1. Takahashi T, Ohsaka A (February 1970). "Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity". Biochimica et Biophysica Acta (BBA) - Enzymology. 198 (2): 293–307. doi:10.1016/0005-2744(70)90062-8. PMID 4984550.
  2. Takeya H, Arakawa M, Miyata T, Iwanaga S, Omori-Satoh T (July 1989). "Primary structure of H2-proteinase, a non-hemorrhagic metalloproteinase, isolated from the venom of the habu snake, Trimeresurus flavoviridis". Journal of Biochemistry. 106 (1): 151–7. doi:10.1093/oxfordjournals.jbchem.a122805. PMID 2777746.
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