Trapidil

Trapidil is a vasodilator and an antiplatelet drug.[1][2] It also acts as an antagonist of platelet-derived growth factor.[3]

Trapidil

Clinical data
Trade names	Rocornal, Avantrin, Travisco
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	C01DX11 (WHO)
Legal status
Legal status	US: Not approved In general: ℞ (Prescription only)
Identifiers
IUPAC name N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
CAS Number	15421-84-8^N
PubChem CID	5531
ChemSpider	5330^N
UNII	EYG5Y6355E
CompTox Dashboard (EPA)	DTXSID0045416
ECHA InfoCard	100.035.834
Chemical and physical data
Formula	C10H15N5
Molar mass	205.265 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)c1cc(nc2n1ncn2)C
InChI InChI=1S/C10H15N5/c1-4-14(5-2)9-6-8(3)13-10-11-7-12-15(9)10/h6-7H,4-5H2,1-3H3^N Key:GSNOZLZNQMLSKJ-UHFFFAOYSA-N^N
^NY (what is this?)  (verify)

References

1. Büyükafşar K, Yazar A, Düşmez D, Oztürk H, Polat G, Levent A (October 2001). "Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats". Pharmacological Research. 44 (4): 321–8. doi:10.1006/phrs.2001.0864. PMID 11592868.
2. Liu M, Sun Q, Wang Q, Wang X, Lin P, Yang M, Yan Y (March–April 2014). "Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit". Indian Journal of Pharmacology. 46 (2): 207–10. doi:10.4103/0253-7613.129320. PMC 3987192. PMID 24741195.
3. Maresta A, Balducelli M, Cantini L, Casari A, Chioin R, Fabbri M, et al. (December 1994). "Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Studio Trapidil versus Aspirin nella Restenosi Coronarica". Circulation. 90 (6): 2710–5. doi:10.1161/01.cir.90.6.2710. PMID 7994812.