Tentoxilysin
Tentoxilysin (EC 3.4.24.68, tetanus neurotoxin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of -Gln76-Phe- bond in synaptobrevin
| Tentoxilysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.68 | ||||||||
| CAS number | 107231-12-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This cinc enzyme produced by Clostridium tetani.
References
- Izumi H, Adachi T, Fujii N, Matsuda T, Nakamura R, Tanaka K, Urisu A, Kurosawa Y (May 1992). "Nucleotide sequence of a cDNA clone encoding a major allergenic protein in rice seeds. Homology of the deduced amino acid sequence with members of alpha-amylase/trypsin inhibitor family". FEBS Letters. 302 (3): 213–6. doi:10.1016/0014-5793(92)80443-k. PMID 1376283.
- Schiavo G, Benfenati F, Poulain B, Rossetto O, Polverino de Laureto P, DasGupta BR, Montecucco C (October 1992). "Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin". Nature. 359 (6398): 832–5. doi:10.1038/359832a0. PMID 1331807.
- Schiavo G, Rossetto O, Santucci A, DasGupta BR, Montecucco C (November 1992). "Botulinum neurotoxins are zinc proteins". The Journal of Biological Chemistry. 267 (33): 23479–83. PMID 1429690.
- Montecucco C, Schiavo G (July 1994). "Mechanism of action of tetanus and botulinum neurotoxins". Molecular Microbiology. 13 (1): 1–8. doi:10.1111/j.1365-2958.1994.tb00396.x. PMID 7527117.
- Schiavo G, Montecucco C (1995). "Tetanus and botulism neurotoxins: isolation and assay". Methods in Enzymology. 248: 643–52. doi:10.1016/0076-6879(95)48041-2. PMID 7674951.
External links
- Tentoxilysin at the US National Library of Medicine Medical Subject Headings (MeSH)
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