TRNAMet cytidine acetyltransferase
TRNAMet cytidine acetyltransferase (EC 2.3.1.193, YpfI, TmcA) is an enzyme with systematic name acetyl-CoA:(elongator tRNAMet)-cytidine34 N4-acetyltransferase (ATP-hydrolysing).[1][2] This enzyme catalyses the following chemical reaction
- [elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA CoA + [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate
| TRNAMet cytidine acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.193 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNAMet.
References
- Ikeuchi Y, Kitahara K, Suzuki T (August 2008). "The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon". The EMBO Journal. 27 (16): 2194–203. doi:10.1038/emboj.2008.154. PMC 2500205. PMID 18668122.
- Chimnaronk S, Suzuki T, Manita T, Ikeuchi Y, Yao M, Suzuki T, Tanaka I (May 2009). "RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon". The EMBO Journal. 28 (9): 1362–73. doi:10.1038/emboj.2009.69. PMC 2683049. PMID 19322199.
External links
- TRNAMet+cytidine+acetyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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