Citrate (Re)-synthase
In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + H2O + oxaloacetate citrate + CoA
| citrate (Re)-synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.3.3 | ||||||||
| CAS number | 9077-70-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are acetyl-CoA, H2O, and oxaloacetate, whereas its two products are citrate and CoA.
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]. Other names in common use include (R)-citrate synthase, Re-citrate-synthase, and citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA].
References
- Dittbrenner S, Chowdhury AA, Gottschalk G (1969). "The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate". Biochem. Biophys. Res. Commun. 36 (5): 802–8. doi:10.1016/0006-291X(69)90680-9. PMID 5808294.
- Gottschalk G (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici". Eur. J. Biochem. 7 (2): 301–6. doi:10.1111/j.1432-1033.1969.tb19607.x. PMID 4974734.
- Gottschalk G, Barker HA (1966). "Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase". Biochemistry. 5 (4): 1125–33. doi:10.1021/bi00868a003. PMID 5958189.
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