Glycerol-3-phosphate O-acyltransferase

In enzymology, a glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15) is an enzyme that catalyzes the chemical reaction

acyl-CoA + sn-glycerol 3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate
glycerol-3-phosphate O-acyltransferase
Identifiers
EC number2.3.1.15
CAS number9029-96-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are acyl-CoA and sn-glycerol 3-phosphate, whereas its two products are CoA and 1-acyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase. Other names in common use include alpha-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate transacylase, sn-glycerol 3-phosphate acyltransferase, and sn-glycerol-3-phosphate acyltransferase. This enzyme participates in glycerolipid metabolism and glycerophospholipid metabolism. The later pathways in human is part of the WikiPathways[1] machine readable pathway collection.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1IUQ and 1K30. Currently 4 different proteins are assigned to this reaction, GPAT1, GPAT2, GPAT3 and GPAT4. GPAT1 and 2 are considered mitochondrial proteins[2][3].

gollark: Also sort of various mesh overlay network things like yggdrasil/cjdns.
gollark: Also tinc and some proprietary things like zerotier/tailscale.
gollark: Although it isn't peer to peer unless you manually set up peer links between them all.
gollark: I think Wireguard can do this.
gollark: I had a version which just used normal forms, but this is much nicer.

References
  1. "Glycerophospholipid Biosynthetic Pathway". WikiPathways. 2019-11-01.
  2. "Uniprot". UniProt. 2019-11-01.
  3. "Uniprot". UniProt. 2019-11-01.


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