Spermine synthase
Spermine synthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosylmethioninamine + spermidine S-methyl-5'-thioadenosine + spermine
| Spermine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.22 | ||||||||
| CAS number | 74812-43-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
References
- Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE (May 1980). "Studies of inhibition of rat spermidine synthase and spermine synthase". The Biochemical Journal. 187 (2): 419–28. PMC 1161808. PMID 7396856.
- Pajula RL, Raina A, Eloranta T (November 1979). "Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain". European Journal of Biochemistry. 101 (2): 619–26. doi:10.1111/j.1432-1033.1979.tb19756.x. PMID 520313.
External links
- Spermine+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.5.1.22
- SMS
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