Ryanoid

Ryanoids are a class of insecticides which share the same mechanism of action as the alkaloid ryanodine. Ryanodine is a naturally occurring insecticide isolated from Ryania speciosa.

Ryanoids include natural chemicals which are closely related to ryanodine, such as ryanodol and 9,21-didehydroryanodol,[1] and also chemically distinct synthetic compounds such as chlorantraniliprole (Rynaxypyr), flubendiamide, and cyantraniliprole which are sometimes called diamide insecticides.[2]

Ryanoids exert their insecticidal effect by interacting with ryanodine receptors, a type of calcium channel. This causes loss of muscle function leading to paralysis and death.

References

1. Usherwood, P.N.R.; Vais, H. (1995). "Towards the development of ryanoid insecticides with low mammalian toxicity". Toxicology Letters. 82-83: 247–54. doi:10.1016/0378-4274(95)03558-3. PMID 8597061.
2. Teixeira, Luís A; Andaloro, John T (2013). "Diamide insecticides: Global efforts to address insect resistance stewardship challenges". Pesticide Biochemistry and Physiology. 106 (3): 76–78. doi:10.1016/j.pestbp.2013.01.010.