Chlorfenapyr

Chlorfenapyr is a pesticide, and specifically a pro-insecticide (meaning it is metabolized into an active insecticide after entering the host), derived from a class of microbially produced compounds known as halogenated pyrroles. The United States Environmental Protection Agency initially denied registration in 2000 for use on cotton primarily because of concerns that the insecticide was toxic to birds and because effective alternatives were available. However, it was registered by the EPA in January, 2001 for use on non-food crops in greenhouses. In 2005, the EPA established a tolerance for residues of chlorfenapyr in or on all food commodities. Chlorfenapyr works by disrupting the production of adenosine triphosphate, specifically, "Oxidative removal of the N-ethoxymethyl group of chlorfenapyr by mixed function oxidases forms the compound CL 303268. CL 303268 uncouples oxidative phosphorylation at the mitochondria, resulting in disruption of production of ATP, cellular death, and ultimately organism mortality."

Chlorfenapyr
Names
IUPAC name
4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethyl-1H-pyrrole-3-carbonitrile
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.116.332
EC Number
  • 602-782-4
KEGG
UNII
Properties
C15H11BrClF3N2O
Molar mass 407.62 g·mol−1
Density 0.543 g/ml tapped bulk density
Melting point 100 to 101 °C (212 to 214 °F; 373 to 374 K)
Hazards
GHS pictograms
GHS Signal word Danger
GHS hazard statements
 H302, H320, H331, H371, H373, H400, H410
P260, P261, P264, P270, P271, P273, P301+312, P304+340, P305+351+338, P309+311, P311, P314, P321, P330, P337+313, P391, P403+233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Chlorfenapyr is also used as a wool insect-proofing agent, and was introduced as an alternative to synthetic pyrethroids due to a lower toxicity to mammalian and aquatic life.[1]

In April 2016, in Pakistan, 31 people died when their food was spiked with chlorfenapyr.[2]

Notes
  1. Ingham, P. E.; McNeil, S. J.; Sunderland, M. R. (2012). "Functional finishes for wool – Eco considerations". Advanced Materials Research. 441: 33–43. doi:10.4028/www.scientific.net/AMR.441.33.
  2. Fred Barbash (May 6, 2016). "31 people suddenly dropped dead in a Pakistani village. Now police claim to know the horrible reason why". Washington Post.

Additional references
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