Russellysin

Russellysin (EC 3.4.24.58, Russell's viper venom factor X activator, RVV-X, blood-coagulation factor X activating enzyme, metalloproteinase RVV-x, Vipera russelli proteinase, Russell's viper blood coagulation factor X activator, RVV-V) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg- bonds. Has no action on insulin B chain
Russellysin
Identifiers
EC number3.4.24.58
CAS number79393-92-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is present in the venom of Russell's viper (Vipera russelli).

References

  1. Furie BC, Furie B (1976). "Coagulant protein of Russell's viper venom". Methods in Enzymology. 45: 191–205. doi:10.1016/s0076-6879(76)45019-x. PMID 1011991.
  2. Lindquist PA, Fujikawa K, Davie EW (March 1978). "Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom". The Journal of Biological Chemistry. 253 (6): 1902–9. PMID 632245.
  3. Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S (July 1992). "Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains". The Journal of Biological Chemistry. 267 (20): 14109–17. PMID 1629211.
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