Ravidasvir

Ravidasvir (PPI-668) is an investigational NS5A inhibitor (by Pharco Pharmaceuticals) in clinical trials for chronic hepatitis C genotype 4.[1]

Ravidasvir

Clinical data
Other names	PPI-668
ATC code	None
Identifiers
IUPAC name (2S)-2-{[Hydroxy(methoxy)methylidene]amino}-1-[(2S)-2-[5-(6-{2-[(2S)-1-[(2S)-2-{[hydroxy(methoxy)methylidene]amino}-3-methylbutanoyl]pyrrolidin-2-yl]-1H-1,3-benzodiazol-6-yl}naphthalen-2-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methylbutan-1-one
CAS Number	1242087-93-9
PubChem CID	52918888
ChemSpider	31141686
UNII	AL3G001BI8
ChEMBL	ChEMBL3121849
Chemical and physical data
Formula	C42H50N8O6
Molar mass	762.912 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC3=C(N2)C=C(C=C3)C4=CC5=C(C=C4)C=C(C=C5)C6=CN=C(N6)[C@@H]7CCCN7C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC
InChI InChI=1S/C42H50N8O6/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,43,46)(H,44,45)(H,47,53)(H,48,54)/t33-,34-,35-,36-/m0/s1 Key:LCHMHYPWGWYXEL-ZYADHFCISA-N

Preliminary clinical trial results were announced in Nov 2015.[2]. In April 2017, press reports stated that a combination treatment involving ravidasvir and sofosbuvir had achieved a 97% clearup rate against hepatitis C in a clinical trial conducted in Malaysia and Thailand, and 100% in another conducted in Egypt.[3]. These trials were supported by the Drugs for Neglected Diseases initiative and funded by the charity Médecins Sans Frontières.

See also

• Discovery and development of NS5A inhibitors

References

1. A Study of the Efficacy and Safety of PPI-668 (NS5A Inhibitor) Plus Sofosbuvir, With or Without Ribavirin, in Patients With Chronic Hepatitis C Genotype-4
2. Good Results for Sovaldi and Ravidasvir Treating Hepatitis C Genotype 4
3. Julia Kollewe, "Non-profit’s $300 hepatitis C cure as effective as $84,000 alternative", The Guardian, 13 April 2018