Procollagen C-endopeptidase

Procollagen C-endopeptidase (EC 3.4.24.19, procollagen C-terminal proteinase, carboxyprocollagen peptidase, procollagen C-terminal peptidase, procollagen C-proteinase, procollagen carboxypeptidase, procollagen carboxy-terminal proteinase, procollagen peptidase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III
Procollagen C-endopeptidase
Identifiers
EC number3.4.24.19
CAS number68651-95-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This endopeptidase belongs to the peptidase family M12 (astacin family).

References

  1. Hojima Y, van der Rest M, Prockop DJ (December 1985). "Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization". The Journal of Biological Chemistry. 260 (29): 15996–6003. PMID 3905801.
  2. Kessler E, Adar R (December 1989). "Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein". European Journal of Biochemistry. 186 (1–2): 115–21. doi:10.1111/j.1432-1033.1989.tb15184.x. PMID 2689170.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.