Peptidyl-Asp metalloendopeptidase
Peptidyl-Asp metalloendopeptidase (EC 3.4.24.33, endoproteinase Asp-N, peptidyl-Asp metalloproteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of Xaa-Asp, Xaa-Glu and Xaa- cysteic acid bonds
| Peptidyl-Asp metalloendopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.33 | ||||||||
| CAS number | 55576-49-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
References
- Porzio MA, Pearson AM (March 1975). "Isolation of an extracellular neutral proteinase from Pseudomonas fragi". Biochimica et Biophysica Acta (BBA) - Enzymology. 384 (1): 235–41. doi:10.1016/0005-2744(75)90112-6. PMID 236771.
- Drapeau GR (February 1980). "Substrate specificity of a proteolytic enzyme isolated from a mutant of Pseudomonas fragi". The Journal of Biological Chemistry. 255 (3): 839–40. PMID 7188696.
- Ingrosso D, Fowler AV, Bleibaum J, Clarke S (August 1989). "Specificity of endoproteinase Asp-N (Pseudomonas fragi): cleavage at glutamyl residues in two proteins". Biochemical and Biophysical Research Communications. 162 (3): 1528–34. doi:10.1016/0006-291x(89)90848-6. PMID 2669754.
- Noreau J, Drapeau GR (December 1979). "Isolation and properties of the protease from the wild-type and mutant strains of Pseudomonas fragi". Journal of Bacteriology. 140 (3): 911–6. doi:10.1128/JB.140.3.911-916.1979. PMC 216733. PMID 42639.
- Hagmann ML, Geuss U, Fischer S, Kresse GB (1995). "Peptidyl-Asp metalloendopeptidase". Methods in Enzymology. 248: 782–7. doi:10.1016/0076-6879(95)48053-6. PMID 7674963.
- Ellard JM, Zollitsch T, Cummins WJ, Hamilton AL, Bradley M (September 2002). "Fluorescence enhancement through enzymatic cleavage of internally quenched dendritic peptides: a sensitive assay for the AspN endoproteinase". Angewandte Chemie. 41 (17): 3233–6. doi:10.1002/1521-3773(20020902)41:17<3233::AID-ANIE3233>3.0.CO;2-E. PMID 12207399.
- Shujia Dai, David H. Lee, Nathaniel T. Kenton and Zhaohui Sunny Zhou (2013). Handbook of Proteolytic Enzymes. Oxford: Academic Press. pp. 1281–1285. ISBN 978-0-12-382219-2.CS1 maint: multiple names: authors list (link)
- Wenqin Ni, Shujia Dai, Barry L. Karger and Zhaohui Sunny Zhou (August 16, 2010). "Analysis of Isoaspartic Acid by Selective Proteolysis with Asp-N and Electron Transfer Dissociation Mass Spectrometry". Analytical Chemistry. 82 (2010, 82 (17)): 7485–7491. doi:10.1021/ac101806e. PMC 2936825. PMID 20712325.CS1 maint: multiple names: authors list (link)
External links
- Peptidyl-Asp+metalloendopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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