Pappalysin-1
Pappalysin-1 (EC 3.4.24.79, insulin-like growth factor binding protein-4 protease, pregnancy-associated plasma protein-A) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Cleavage of the Met135-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-Lys bond in IGFBP-5
| Pappalysin-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.79 | ||||||||
| CAS number | 151662-33-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme belongs to the peptidase family M43.
References
- Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR, Conover CA (March 1999). "The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A". Proceedings of the National Academy of Sciences of the United States of America. 96 (6): 3149–53. Bibcode:1999PNAS...96.3149L. doi:10.1073/pnas.96.6.3149. PMC 15910. PMID 10077652.
- Chen BK, Overgaard MT, Bale LK, Resch ZT, Christiansen M, Oxvig C, Conover CA (April 2002). "Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor". Endocrinology. 143 (4): 1199–205. doi:10.1210/endo.143.4.8729. PMID 11897673.
External links
- Pappalysin-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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