Oxetacaine

Oxetacaine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, topical
ATC code	C05AD06 (WHO) ;
Pharmacokinetic data
Elimination half-life	1 hour
Identifiers
	IUPAC name 2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide];
CAS Number	126-27-2 ;
PubChem CID	4621;
ChemSpider	4460 ;
UNII	IP8QT76V17;
KEGG	D01152 ;
ChEMBL	ChEMBL127592 ;
CompTox Dashboard (EPA)	DTXSID0025818 ;
ECHA InfoCard	100.004.346
Chemical and physical data
Formula	C28H41N3O3
Molar mass	467.654 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N(C(C)(C)Cc1ccccc1)C)CN(CCO)CC(=O)N(C(Cc2ccccc2)(C)C)C;
	InChI InChI=1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3 ; Key:FTLDJPRFCGDUFH-UHFFFAOYSA-N ;
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Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan, Taiwan and Brazil, but not the United States.

Unlike most local anesthetics, oxetacaine does not break down under strongly acidic conditions.[1]

References

Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med. 109: 664–8. doi:10.3181/00379727-109-27300. PMID 13910333.

External links

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[1] Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med. 109: 664–8. doi:10.3181/00379727-109-27300. PMID 13910333.