Olsalazine

Olsalazine is an anti-inflammatory drug used in the treatment of inflammatory bowel disease such as ulcerative colitis. It is sold under the name Dipentum.

Olsalazine
Clinical data
Trade namesDipentum
AHFS/Drugs.comMonograph
MedlinePlusa601088
Pregnancy
category
  • US: C (Risk not ruled out)
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    Protein binding99%
    Elimination half-life0.9 hours
    Identifiers
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.116.494
    Chemical and physical data
    FormulaC14H10N2O6
    Molar mass302.242 g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.

    Like balsalazide, olsalazine is believed to deliver mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.

    History

    Olsalazine gained Food and Drug Administration (FDA) approval in 1990.

    Supply

    The drug is supplied by UCB Pharma.

    Other indications

    The Australian biotech company Giaconda has developed a combination therapy for treating constipation-predominant irritable bowel syndrome that uses olsalazine and the anti-gout drug colchicine.

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