Neurolysin

Neurolysin (EC 3.4.24.16, neurotensin endopeptidase, endopeptidase 24.16, endo-oligopeptidase B (proline-endopeptidase)) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Preferential cleavage in neurotensin: Pro10-Tyr
Neurolysin
Identifiers
EC number3.4.24.16
CAS number149371-24-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme belongs to the peptidase family M3.

References

  1. Checler F, Vincent JP, Kitabgi P (August 1986). "Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes". The Journal of Biological Chemistry. 261 (24): 11274–81. PMID 3525564.
  2. Barelli H, Vincent JP, Checler F (August 1988). "Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum". European Journal of Biochemistry. 175 (3): 481–9. doi:10.1111/j.1432-1033.1988.tb14220.x. PMID 3409880.
  3. Checler F, Barelli H, Vincent JP (January 1989). "Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies". The Biochemical Journal. 257 (2): 549–54. PMC 1135613. PMID 2649078.
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