Muromegalovirus

Muromegalovirus
Virus classification
(unranked):	Virus
Realm:	Duplodnaviria
Kingdom:	Heunggongvirae
Phylum:	Peploviricota
Class:	Herviviricetes
Order:	Herpesvirales
Family:	Herpesviridae
Subfamily:	Betaherpesvirinae
Genus:	Muromegalovirus
Type species
	Murid betaherpesvirus 1;
Species
	See text

Muromegalovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Rodents serve as natural hosts. There are currently three species in this genus including the type species Murid betaherpesvirus 1. Diseases associated with this genus include: infected peritoneal macrophages, dendritic cells (DC) and hepatocytes, inducing significant pathology in both the spleen and the liver.[1][2] Murid viruses Murid betaherpesvirus 1 (MuHV-1) and Murid betaherpesvirus 2 (MuHV-2), previously defined as mouse cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV), belong to this genus.[3]

Species

The genus consists of the following three species:[2]

Structure

Viruses in Muromegalovirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 230kb in length.[1]

Genus	Structure	Symmetry	Capsid	Genomic arrangement	Genomic segmentation
Muromegalovirus	Spherical pleomorphic	T=16	Enveloped	Linear	Monopartite

Life cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding. Rodents serve as the natural host.[1]

Genus	Host details	Tissue tropism	Entry details	Release details	Replication site	Assembly site	Transmission
Muromegalovirus	Rodents	Salivary glands	Glycoprotiens	Budding	Nucleus	Nucleus	Contact

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References

"Viral Zone". ExPASy. Retrieved 15 June 2015.
ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.
Koichi Yamanishi; Arvin, Ann M.; Gabriella Campadelli-Fiume; Edward Mocarski; Moore, Patrick; Roizman, Bernard; Whitley, Richard (2007). Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge, UK: Cambridge University Press. ISBN 0-521-82714-0.

External links

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[ViralZone-1] "Viral Zone". ExPASy. Retrieved 15 June 2015.

[ICTV-2] ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.

[isbn0-521-82714-0-3] Koichi Yamanishi; Arvin, Ann M.; Gabriella Campadelli-Fiume; Edward Mocarski; Moore, Patrick; Roizman, Bernard; Whitley, Richard (2007). Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge, UK: Cambridge University Press. ISBN 0-521-82714-0.