Mydriasis

Mydriasis is the dilation of the pupil, usually having a non-physiological cause,[2] or sometimes a physiological pupillary response.[3] Non-physiological causes of mydriasis include disease, trauma, or the use of drugs.

Mydriasis
Other namesBlown pupil[1]
Pupil dilated for examination by ophthalmologist
Pronunciation
  • /mɪˈdraɪ.əsɪs/
SpecialtyOphthalmology, neurology

Normally, as part of the pupillary light reflex, the pupil dilates in the dark and constricts in the light to respectively improve vividity at night and to protect the retina from sunlight damage during the day. A mydriatic pupil will remain excessively large even in a bright environment. The excitation of the radial fibres of the iris which increases the pupillary aperture is referred to as a mydriasis. More generally, mydriasis also refers to the natural dilation of pupils, for instance in low light conditions or under sympathetic stimulation.

Fixed, unilateral mydriasis could be a symptom of raised intracranial pressure. The opposite, constriction of the pupil, is referred to as miosis. Both mydriasis and miosis can be physiological. Anisocoria is the condition of one pupil being more dilated than the other.

Causes

There are two types of muscle that control the size of the iris: the iris sphincter, composed of circularly arranged muscle fibers, and the iris dilator, composed of radially arranged muscle fibers. The sphincter is innervated by (signaled by nerves of) the parasympathetic nervous system, and the dilator by the sympathetic nervous system. Sympathetic stimulation of the adrenergic receptors causes the contraction of the radial muscle and subsequent dilation of the pupil. Conversely, parasympathetic stimulation causes contraction of the circular muscle and constriction of the pupil.

The mechanism of mydriasis depends on the agent being used. It usually involves either a disruption of the parasympathetic nerve supply to the eye (which normally constricts the pupil) or overactivity of the sympathetic nervous system (SNS).

Pupil diameter also increases in reaction to cognitive tasks requiring memory and attention, and this phenomenon is used as an indicator of mental activation (‘arousal’) in psychophysiological experiments.[4]

Drugs

A mydriatic is an agent that induces dilation of the pupil. Drugs such as tropicamide are used in medicine to permit examination of the retina and other deep structures of the eye, and also to reduce painful ciliary muscle spasm (see cycloplegia). One effect of administration of a mydriatic is intolerance to bright light (photophobia). Purposefully-induced mydriasis via mydriatics is also used as a diagnostic test for Horner's syndrome.

Mydriasis can be induced via modulation of adrenergic or cholinergic signalling.

Drugs that can cause mydriasis include:

Natural release of the hormone oxytocin can cause mild to moderate mydriasis.

Long term effects of drugs can also cause mydriasis, for example opioid withdrawal.

Autonomic neuropathy

Parasympathetic fibers travel with cranial nerve III, the oculomotor nerve, to innervate the circular layer of muscle of the eye (sphincter pupillae). Damage to this nerve typically manifests itself as mydriasis, because the sympathetic supply to the pupil, which causes mydriasis, remains unaffected, and therefore unopposed.

Multiple central nervous system disorders e.g. epilepsy, stroke, and impending brain herniation are known to lead to temporal mydriasis as well. A brain catastrophe, or a rapidly increasing brain mass, can cause compression of the oculomotor nerve.

Trauma

In cases of head injury or orbit trauma (eye injury), the iris sphincter (the muscle responsible for closing the pupil) or the nerves controlling it can be damaged, reducing or eliminating the normal pupillary light reflex.

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References
  1. "Traumatic Brain Injury". American Association of Neurological Surgeons. Retrieved 27 March 2012.
  2. Mydriasis in Farlex medical dictionary. In turn citing:
    • The American Heritage Medical Dictionary (2007)
    • Mosby's Dental Dictionary, 2nd edition.
  3. Mydriasis in Farlex medical dictionary. In turn citing: Mosby's Medical Dictionary, 8th edition.
  4. Koss MC. Pupillary dilation as an index of central nervous system alpha 2-adrenoceptor activation. J Pharmacol Methods. 1986;15:1–19. [PubMed]...Peavler WS. Pupil size, information overload, and performance differences. Psychophysiology. 1974;11:559–566. [PubMed]...Laeng B, Sirois S, Gredebäck G. Pupillometry: a window to the preconscious? Perspect Psychol Sci. 2012;7:18–27. [PubMed]...Kloosterman NA, Meindertsma T, van Loon AM, Lamme VA, Bonneh YS, Donner TH. Pupil size tracks perceptual content and surprise. Eur J Neurosci. 2015;41:1068–1078. [PubMed]
  5. Saenz-de-Viteri, Manuel; Gonzalez-Salinas, Roberto; Guarnieri, Adriano; Guiaro-Navarro, María Concepción (2016). "Patient considerations in cataract surgery – the role of combined therapy using phenylephrine and ketorolac". Patient Preference and Adherence. 10: 1795–1801. doi:10.2147/PPA.S90468. ISSN 1177-889X. PMC 5029911. PMID 27695298.
  6. "Cyclomydril - FDA prescribing information, side effects and uses".
  7. "Common eye diseases and their management", Galloway/Amoako/Browning, Springer science 2006, 3rd edition, p196
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