Methanol dehydrogenase (nicotinoprotein)

Methanol dehydrogenase (nicotinoprotein) (EC 1.1.99.37, NDMA-dependent methanol dehydrogenase, nicotinoprotein methanol dehydrogenase, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name methanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

methanol + acceptor formaldehyde + reduced acceptor
Methanol dehydrogenase (nicotinoprotein)
Identifiers
EC number1.1.99.37
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme contains Zn2+ and Mg2+.

References
  1. Vonck J, Arfman N, De Vries GE, Van Beeumen J, Van Bruggen EF, Dijkhuizen L (February 1991). "Electron microscopic analysis and biochemical characterization of a novel methanol dehydrogenase from the thermotolerant Bacillus sp. C1". The Journal of Biological Chemistry. 266 (6): 3949–54. PMID 1995642.
  2. Van Ophem PW, Van Beeumen J, Duine JA (March 1993). "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". European Journal of Biochemistry. 212 (3): 819–26. doi:10.1111/j.1432-1033.1993.tb17723.x. PMID 8385013.
  3. Bystrykh LV, Vonck J, van Bruggen EF, van Beeumen J, Samyn B, Govorukhina NI, Arfman N, Duine JA, Dijkhuizen L (March 1993). "Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol: N,N'-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19". Journal of Bacteriology. 175 (6): 1814–22. doi:10.1128/jb.175.6.1814-1822.1993. PMC 203978. PMID 8449887.
  4. Hektor HJ, Kloosterman H, Dijkhuizen L (December 2002). "Identification of a magnesium-dependent NAD(P)(H)-binding domain in the nicotinoprotein methanol dehydrogenase from Bacillus methanolicus". The Journal of Biological Chemistry. 277 (49): 46966–73. doi:10.1074/jbc.M207547200. PMID 12351635.
  5. Park H, Lee H, Ro YT, Kim YM (February 2010). "Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803)". Microbiology. 156 (Pt 2): 463–71. doi:10.1099/mic.0.034124-0. PMID 19875438.
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