Malate dehydrogenase (oxaloacetate-decarboxylating)

In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) (EC 1.1.1.38) is an enzyme that catalyzes the chemical reaction

(S)-malate + NAD+ pyruvate + CO2 + NADH
malate dehydrogenase (oxaloacetate-decarboxylating)
malic enzyme tetramer, Human
Identifiers
EC number1.1.1.38
CAS number9080-52-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are (S)-malate and NAD+, whereas its 3 products are pyruvate, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include malic enzyme, pyruvic-malic carboxylase, NAD+-specific malic enzyme, NAD+-malic enzyme, and NAD+-linked malic enzyme. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1DO8, 1EFK, 1EFL, 1GZ3, 1LLQ, 1O0S, 1PJ2, 1PJ3, 1PJ4, 1PJL, 1QR6, 1WW8, and 2DVM.

gollark: So basically, the "god must exist because the universe is complex" thing ignores the fact that it... isn't really... and that gods would be pretty complex too, and does not answer any questions usefully because it just pushes off the question of why things exist to why *god* exists.
gollark: To randomly interject very late, I don't agree with your reasoning here. As far as physicists can tell, while pretty complex and hard for humans to understand, relative to some other things the universe runs on simple rules - you can probably describe the way it works in maybe a book's worth of material assuming quite a lot of mathematical background. Which is less than you might need for, say, a particularly complex modern computer system. You know what else is quite complex? Gods. They are generally portrayed as acting fairly similarly to humans (humans like modelling other things as basically-humans and writing human-centric stories), and even apart from that are clearly meant to be intelligent agents of some kind. Both of those are complicated - the human genome is something like 6GB, a good deal of which probably codes for brain things. As for other intelligent things, despite having tons of data once trained, modern machine learning things are admittedly not very complex to *describe*, but nobody knows what an architecture for general intelligence would look like.
gollark: https://media.discordapp.net/attachments/348702212110680064/896356765267025940/FB_IMG_1633757163544.jpg
gollark: https://isotropic.org/papers/chicken.pdf
gollark: Frankly, go emit muon neutrinos.

See also

References

    • Kaufman S, Korkes S, Del Campillo A (1951). "Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V Further studies of the "malic" enzyme of Lactobacillus arabinosus". J. Biol. Chem. 192: 301–312.
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