Leucolysin

Leucolysin (EC 3.4.24.6, Leucostoma neutral proteinase, Leucostoma peptidase A) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of Phe1-Val, His5-Leu, Ala14-Leu, Gly20-Glu, Gly23-Phe and Phe24-Phe bonds in insulin B chain as well as N-blocked dipeptides
Leucolysin
Identifiers
EC number3.4.24.6
CAS number72561-03-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).

References

  1. Wagner FW, Spiekerman AM, Prescott JM (September 1968). "Leucostoma peptidase A. Isolation and physical properties". The Journal of Biological Chemistry. 243 (17): 4486–93. PMID 5684005.
  2. Spiekerman AM, Fredericks KK, Wagner FW, Prescott JM (February 1973). "Leucostoma peptidase A: a metalloprotease from snake venom". Biochimica et Biophysica Acta (BBA) - Enzymology. 293 (2): 464–75. doi:10.1016/0005-2744(73)90353-7. PMID 4711816.
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