Jararhagin

Jararhagin (EC 3.4.24.73, HF2-proteinase, JF1) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of -His10-Leu-, -Ala14-Leu-, -Tyr16-Leu-and -Phe24-Phe- bonds in insulin B chain
Jararhagin
Identifiers
EC number3.4.24.73
CAS number160477-79-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This endopeptidase is present in the venom of the jararaca snake (Bothrops jararaca).

References

  1. Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). "Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca". In Ohsaka, A., Hayashi, K. and Sawai, Y. (ed.). Animal, Plant and Microbial Toxins. New York: Plenum Press. pp. 111–121.CS1 maint: multiple names: authors list (link)
  2. Assakura MT, Reichl AP, Mandelbaum FR (1986). "Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)". Toxicon. 24 (9): 943–6. doi:10.1016/0041-0101(86)90094-2. PMID 3810664.
  3. Paine MJ, Desmond HP, Theakston RD, Crampton JM (November 1992). "Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family". The Journal of Biological Chemistry. 267 (32): 22869–76. PMID 1385408.
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