Iron(III) pyrophosphate

Ferric pyrophosphate citrate
Clinical data
Trade names	Triferic, Triferic AVNU
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Ferric_pyrophosphate;
Routes of; administration	Hemodialysis, intravenous (IV), parenteral
ATC code	none;
Legal status
Legal status	US: ℞-only ;
Identifiers
PubChem CID	109374151;
DrugBank	DB13995;
ChemSpider	34994433;
UNII	UBY79OCO9G;
KEGG	D10933;
ChEMBL	ChEMBL3833317;
CompTox Dashboard (EPA)	DTXSID6047600 ;
ECHA InfoCard	100.030.160
Chemical and physical data
Formula	C18H24Fe4O42P6
Molar mass	1321.571 g·mol−1

Iron(III) pyrophosphate
Names
	Other names Ferric pyrophosphate
Identifiers
CAS Number	10058-44-3 (anhydrous) ; 10049-18-0 (nonahydrate) ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:132767;
ChemSpider	23258;
DrugBank	DB09147;
ECHA InfoCard	100.030.160
EC Number	233-190-0;
PubChem CID	24877;
UNII	QK8899250F;
CompTox Dashboard (EPA)	DTXSID6047600 ;
	InChI Key: CADNYOZXMIKYPR-UHFFFAOYSA-B; InChI=1S/4Fe.3H4O7P2/c;;;;31-8(2,3)7-9(4,5)6/h;;;;3(H2,1,2,3)(H2,4,5,6)/q4*+3;;;/p-12;
	SMILES [Fe+3].O=P([O-])([O-])OP(=O)([O-])[O-].[Fe+3].O=P([O-])([O-])OP(=O)([O-])[O-].[Fe+3].O=P([O-])([O-])OP(=O)([O-])[O-].[Fe+3];
Properties
Chemical formula	Fe4(P2O7)3
Molar mass	745.224 (anhydrate); 907.348 (nonahydrate)
Appearance	yellow solid (nonahydrate)[1]
Solubility in water	insoluble
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Iron(III) pyrophosphate is an inorganic chemical compound with the formula Fe₄(P₂O₇)₃.

Medical uses

Ferric pyrophosphate citrate, sold under the brand name Triferic, is an iron replacement product indicated for the replacement of iron to maintain hemoglobin in adults with hemodialysis-dependent chronic kidney disease.[2][3]

The most common adverse reactions include headache, peripheral edema, asthenia, AV fistula thrombosis, urinary tract infection, AV fistula site hemorrhage, pyrexia, fatigue, procedural hypotension, muscle spasms, pain in extremity, back pain, and dyspnea.[2]

Ferric pyrophosphate citrate was approved for medical use in the United States in January 2015.[4]

Ferric pyrophosphate citrate is a mixed-ligand iron complex in which iron (III) is bound to pyrophosphate and citrate.[2]

Synthesis

Anhydrous iron(III) pyrophosphate can be prepared by heating the mixture of iron(III) metaphosphate and iron(III) phosphate under oxygen with the stoichiometric ratio 1:3. The reactants can be prepared by reacting iron(III) nitrate nonahydrate with phosphoric acid.[5]

It can be also prepared via the following reaction:[6]

3 Na₄P₂O₇(aq) + 4 FeCl₃(aq) → Fe₄(P₂O₇)₃(s) + 12 NaCl(aq)

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References

W.M.Haynes. CRC Handbook of Chemistry and Physics (97th edition). New York: CRC Press, 2016. pp 4-68
"Triferic- ferric pyrophosphate solution Triferic- ferric pyrophosphate citrate powder Triferic- ferric pyrophosphate citrate solution". DailyMed. 1 November 2019. Retrieved 30 April 2020.
"Triferic AVNU- ferric pyrophosphate citrate solution". DailyMed. 6 April 2020. Retrieved 30 April 2020.
"Triferic (ferric pyrophosphate citrate) solution". U.S. Food and Drug Administration (FDA). 2 March 2016. Retrieved 30 April 2020.
Elbouaanani, L.K; Malaman, B; Gérardin, R; Ijjaali, M (2002). "Crystal Structure Refinement and Magnetic Properties of Fe4(P2O7)3 Studied by Neutron Diffraction and Mössbauer Techniques". Journal of Solid State Chemistry. Elsevier BV. 163 (2): 412–420. doi:10.1006/jssc.2001.9415. ISSN 0022-4596.
Rossi L, Velikov KP, Philipse AP (May 2014). "Colloidal iron(III) pyrophosphate particles". Food Chem. 151: 243–7. doi:10.1016/j.foodchem.2013.11.050. PMID 24423528.

External links

"Ferric pyrophosphate". Drug Information Portal. U.S. National Library of Medicine.
"Ferric pyrophosphate citrate". Drug Information Portal. U.S. National Library of Medicine.

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[1] W.M.Haynes. CRC Handbook of Chemistry and Physics (97th edition). New York: CRC Press, 2016. pp 4-68

[Triferic_FDA_label-2] "Triferic- ferric pyrophosphate solution Triferic- ferric pyrophosphate citrate powder Triferic- ferric pyrophosphate citrate solution". DailyMed. 1 November 2019. Retrieved 30 April 2020.

[Triferic_AVNU_FDA_label-3] "Triferic AVNU- ferric pyrophosphate citrate solution". DailyMed. 6 April 2020. Retrieved 30 April 2020.

[4] "Triferic (ferric pyrophosphate citrate) solution". U.S. Food and Drug Administration (FDA). 2 March 2016. Retrieved 30 April 2020.

[5] Elbouaanani, L.K; Malaman, B; Gérardin, R; Ijjaali, M (2002). "Crystal Structure Refinement and Magnetic Properties of Fe4(P2O7)3 Studied by Neutron Diffraction and Mössbauer Techniques". Journal of Solid State Chemistry. Elsevier BV. 163 (2): 412–420. doi:10.1006/jssc.2001.9415. ISSN 0022-4596.

[6] Rossi L, Velikov KP, Philipse AP (May 2014). "Colloidal iron(III) pyrophosphate particles". Food Chem. 151: 243–7. doi:10.1016/j.foodchem.2013.11.050. PMID 24423528.