IL31RA

Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.[5][6][7]

IL31RA
Identifiers
Aliases	IL31RA, CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, interleukin 31 receptor A
External IDs	OMIM: 609510 MGI: 2180511 HomoloGene: 51395 GeneCards: IL31RA
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 55,851,357 bp[1] End 55,922,854 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 112,519,898 bp[2] End 112,594,360 bp[2]
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • cytokine receptor activity • protein kinase binding • cytokine binding Cellular component • membrane • external side of plasma membrane • cell membrane • synapse • cell junction • integral component of membrane • axon • intracellular • presynaptic membrane • cell projection • receptor complex Biological process • defense response • JAK-STAT cascade • transmembrane receptor protein tyrosine kinase signaling pathway • cytokine-mediated signaling pathway • immune system process • defense response to other organism • negative regulation of macrophage activation • negative regulation of apoptotic process • acute inflammatory response to antigenic stimulus • monocyte differentiation • macrophage differentiation • MAPK cascade • positive regulation of transcription, DNA-templated • glandular epithelial cell differentiation • positive regulation of cell proliferation • T-helper 2 cell cytokine production • homeostatic process • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	133396	218624
Ensembl	ENSG00000164509	ENSMUSG00000050377
UniProt	Q8NI17	Q8K5B1
RefSeq (mRNA)	NM_001242636 NM_001242637 NM_001242638 NM_001242639 NM_001297570 NM_001297572 NM_139017	NM_139299
RefSeq (protein)	NP_001229565 NP_001229566 NP_001229567 NP_001229568 NP_001284499 NP_001284501 NP_620586	NP_647460
Location (UCSC)	Chr 5: 55.85 – 55.92 Mb	Chr 13: 112.52 – 112.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000164509 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050377 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (Jun 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896.
6. Ghilardi N, Li J, Hongo JA, Yi S, Gurney A, de Sauvage FJ (May 2002). "A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5". J Biol Chem. 277 (19): 16831–6. doi:10.1074/jbc.M201140200. PMID 11877449.
7. "Entrez Gene: IL31RA interleukin 31 receptor A".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Diveu C, Lelièvre E, Perret D, et al. (2004). "GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor". J. Biol. Chem. 278 (50): 49850–9. doi:10.1074/jbc.M307286200. PMID 14504285.
• Dreuw A, Radtke S, Pflanz S, et al. (2005). "Characterization of the signaling capacities of the novel gp130-like cytokine receptor". J. Biol. Chem. 279 (34): 36112–20. doi:10.1074/jbc.M401122200. PMID 15194700.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Diveu C, Lak-Hal AH, Froger J, et al. (2005). "Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling". Eur. Cytokine Netw. 15 (4): 291–302. PMID 15627637.
• Bilsborough J, Leung DY, Maurer M, et al. (2006). "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis". J. Allergy Clin. Immunol. 117 (2): 418–25. doi:10.1016/j.jaci.2005.10.046. PMID 16461143.